Pilot study of ketamine in pyschogenic non-epileptic seizures.

Phase 2

• Conditions: Psychogenic non-epileptic seizures; Neurological - Other neurological disorders

• Registration Number: ACTRN12621001127897
• Lead Sponsor: Department of Psychological medicine, Otago University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-08-23
• Last Update Posted: 30 August 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1.Capable of understanding and signing an informed consent
2.Aged >18 years on the day of consent.
3.Have an established diagnosis of PNES by a neurologist and have failed to benefit from psychoeducation using the explanation suggested

Exclusion Criteria

To be included in the study, participants must meet none of the following exclusion criteria:
1.Female participants who are or intend to become pregnant, or are lactating
2.Participants who, in the opinion of the investigator, do not understand the information and procedures of the study, or would not be compliant with them (in particular the study restrictions and risks involved).
3.Any participant for whom the investigator believes, for any reason, that participation would not be an acceptable risk.
4.Starting new antidepressants, anxiolytics or psychotherapy within 4 weeks of enrolment. Use of antidepressants, anxiolytics at stable doses > 4 weeks prior or psychotherapy is acceptable.
5.Participants with severe acute or chronic medical illnesses.
6.Participants with comorbid schizophrenia, bipolar disorder and severe personality disorders, comorbid depression and anxiety is acceptable
7.Participants with current drug or alcohol abuse problems
8.Participants with current active suicidal ideation
9.Participants with any current controlled or uncontrolled epileptic seizures as diagnosed by a neurologist

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in average NES frequency as measured with a seizure diary <br>[From participants entry until 16 weeks with daily entry to diary for seizure activities <br>]