Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 3,263
- Locations
- 1
- Primary Endpoint
- predictability of prognostic nutritional index for mortality after brain tumor surgery
Study Overview
Brief Summary
There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.
Detailed Description
In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea
Exclusion Criteria
- •Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol
- •Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome
Arms & Interventions
brain tumor surgery
adult patients undergoing brain tumor surgery
Intervention: prognostic nutritional index calculated from laboratory parameters (Diagnostic Test)
Outcomes
Primary Outcomes
predictability of prognostic nutritional index for mortality after brain tumor surgery
Time Frame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years
Odds ratio of prognostic nutritional index for postoperative mortality
Secondary Outcomes
- predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery(From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years)
- relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery(From date of surgery until the date of hospital discharge)
- predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery(From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years)
Investigators
Youn Joung Cho, MD, PhD
Clinical Associate Professor
Seoul National University Hospital