Comparison of Dexmedetomidine and Dexamethasone as Adjuvant to Bupivacaine in Ultrasound-guided Bilevel Erector Spinae Plane Block in Modified Radical Mastectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Total morphine consumption in the first 24 hours postoperatively.
研究概览
简要总结
High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain. Several techniques are adopted to control perioperative pain, these techniques include drugs as opioids and adjuvants as well as regional blocks. Erector spinae plane block is a regional technique that is used efficiently to control perioperative pain during and following breast cancer surgeries.
详细描述
High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain. Several techniques are adopted to control perioperative pain, these techniques include drugs as opioids and adjuvants as well as regional blocks. Erector spinae plane block is a regional technique that is used efficiently to control perioperative pain during and following breast cancer surgeries. Adding adjuvant drugs as dexmedetomidine or dexamethasone can augment the local anesthetic effect for the regional block used.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients scheduled for Modified Radical Mastectomy MRM
- •Physical status ASA II, III.
- •Age (18-65) years
- •Body mass index (BMI): (20-35) kg/m2.
排除标准
- •Patient refusal.
- •Age <18 years or >65 years.
- •BMI <20 kg/m2 and >35 kg/m
- •Known sensitivity or contraindication to drug used in the study (local anaesthetics, opioids, dexamethasone, dexmedetomedine).
研究组 & 干预措施
Intravenous morphine
Patients will receive intravenous morphine 0.1 mg/kg
干预措施: Intravenous morphine (Drug)
Bilevel erector spinae plane block
Patients will receive erector spinae plane block at 2 levels
干预措施: Bilevel Erector spinae plane block (Procedure)
Bilevel erector spinae plane block with dexamethasone
Patients will receive erector spinae plane block at 2 levels with dexamethasone
干预措施: Bilateral Erector spinae plane block with dexamethasone (Procedure)
Bilevel erector spinae plane block with dexmedetomidine
Patients will receive erector spinae plane block at 2 levels with dexmedetomidine
干预措施: Bilateral Erector spinae plane block with dexmedetomidine (Procedure)
结局指标
主要结局
Total morphine consumption in the first 24 hours postoperatively.
时间窗: First 24 hours postoperatively
Assessment of total postoperative morphine consumption
次要结局
未报告次要终点
研究者
Walaa Youssef Elsabeeny
Assistant professor of Anesthesia and Pain management
National Cancer Institute, Egypt