Recalibration of audio-visual synchronicity and its impact on perception in children and adolescents with autism spectrum disorder

Not Applicable

Recruiting

• Conditions: F84.0; F84.1; F84.5; Childhood autism; Atypical autism; Asperger syndrome

• Registration Number: DRKS00032847
• Lead Sponsor: Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie der Medizinischen Hochschule Hannover

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Presence or exclusion (in the control group) of ASD (also applies to first-degree relatives)
- Fluent speech

Exclusion Criteria

- Known genetic or current neurological disease affecting the CNS
- Use of psychoactive substances
- Uncorrected visual impairment
- Hearing impairment
- Dyslexia

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is the effect of the multisensory training on the temporal binding window. To determine the size of the temporal integration window, sigmoid curves are fitted for each individual, which represent the mean value of the synchrony judgment for each stimulus-onset asynchrony (SOA). For each SOA, the probability that the participant perceives the presented stimuli as synchronous is determined. The size of the temporal integration window is defined as the width of the distribution (in ms) at a 75% probability of perceiving the presented stimuli as synchronous. The multisensory training is considered successful when there is a significant reduction in the size of the temporal binding window after the training. The size of the temporal binding window is estimated directly before (T0) and after the multisensory training (T1), and 7 (T3) and 14 days (T4) after the multisensory training.

Secondary Outcome Measures

Name	Time	Method
The secondary outcome is the dynamic change in the size of the temporal binding window at the level of individual trials, referred to as rapid recalibration of audiovisual integration. In addition, the improvement of performance in the Word Recognition Task (WRT), quantified by the percentage of correct answers, is an important secondary outcome. The secondary outcomes will also be analyzed at T0-T4 and compared between groups.