A study comparing the effects of two drugs, Dexmedetomidine and Fentanyl, on the blood pressure and heart rate in patients with high blood pressure, undergoing major surgery
Phase 4
- Conditions
- Health Condition 1: null- HypertensiveAmerican Society of Anesthesiologists (ASA) 2 physical status
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Hypertensive patients under American Society of Anesthesiologists (ASA) Physical status 2 posted for major surgery under general anaesthesia.
Exclusion Criteria
1. Systolic BP > 160mmHg, Diastolic BP >100mmHg
2. H/o ischemic heart disease
3. H/o cerebral vascular disease
4. Impaired renal function tests
4. Impaired liver function tests
5. Laparoscopic procedure
6. Pregnant and suspected full-stomach patients
7. Anticipated difficult airway
8. Surgery with expected significant blood loss ( >25%of blood volume) and fluid shifts
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the effect of intravenous Dexmedetomidine on intra operative hemodynamics in hypertensive patients and compare it with The effect of intravenous FentanylTimepoint: To study the effect of intravenous Dexmedetomidine on intra operative hemodynamics in hypertensive patients and compare it with The effect of intravenous Fentanyl
- Secondary Outcome Measures
Name Time Method Opioid consumption <br/ ><br> <br/ ><br>Timepoint: Intra operative <br/ ><br>;Time to recover from anesthesia (eye opening to verbal call)Timepoint: End operative;Time to first analgesic requestTimepoint: Post operative