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Clinical Trials/NCT01730599
NCT01730599UnknownNot Applicable

A Longitudinal 5 Years Follow up Study in Parkinson's Disease (PD) Patients Carriers of the LRRK2 Gene G2019S Mutation

Tel-Aviv Sourasky Medical Center1 site in 1 country200 target enrollmentStarted: November 2012Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Enrollment
200
Locations
1
Primary Endpoint
change from baseline in updrs motor and total scores
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up

Study Design

Study Type
Observational
Observational Model
Cohort

Eligibility Criteria

Ages
30 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •parkinson'd disease patients that already participated in a pasr cross sectional study

Exclusion Criteria

  • •subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV
  • •subjects with psychiatric disorder
  • •subjects unable to sign a consent form

Outcomes

Primary Outcomes

change from baseline in updrs motor and total scores

Time Frame: the participants will be followed for 5 years. the measurements will be taken evry 18 month.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other Gov
Responsible Party
Sponsor

Study Sites (1)

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A Longitudinal Study in Parkinson's... | Clinical Trial