Extracardiac Complications After Cardiopulmonary by Pass in Cardiac Surgery
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Turin, Italy
- Enrollment
- 164
- Locations
- 1
- Primary Endpoint
- Acute Lung Injury After Cardiac Surgery
Overview
Brief Summary
Hypothesis of the study is that patients undergoing major cardiac surgery can develop extracardiac complications correlated to cardiopulmonary by pass.
Detailed Description
To find out which are the main peri operative predictors of acute lung injury and other extracardiac complications, such as kidney injury, that prolonged Intensive Care Unit (ICU) length of stay after cardiac surgery. The main goal is to evaluate whether mechanical ventilation, in particular tidal volume, can be predictor of acute lung injure in this kind of patients.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •cardiac intervention with cardiopulmonary by pass, age \> 18 years old
Exclusion Criteria
- •off-pump surgery, heart and lung transplantations, patients on mechanical ventilation before intervention or admitted to Intensive Care Unit (ICU) before intervention.
Outcomes
Primary Outcomes
Acute Lung Injury After Cardiac Surgery
Time Frame: at seven days after intervention
to evaluate the incidence of acute lung injury (ALI) in patients undergoing cardiac surgery with cardiopulmonary by pass and to identify the main predictors.Diagnosis of Acute Lung Injury (ALI) was made according to the American-European Consensus conference criteria, including acute onset, PaO2 /FiO2 \<300 regardless of Positive End Expiratory Pressure (PEEP) level, bilateral and diffuse opacities on chest radiograph, absence of left ventricular failure, or history of lung disease.
Secondary Outcomes
- Intensive Care Unit (ICU) Length of Stay(at 28 days)
Investigators
Daniela Pasero
MD
University of Turin, Italy