Brain Injury in Surgery Study

Not Applicable

• Conditions: Peri-operative cerebral ischemia; Stroke - Ischaemic

• Registration Number: ACTRN12610000005055
• Lead Sponsor: Auckland City Hospital Research Review Committee

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-01-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1.Thirty consecutive patients undergoing bowel surgery (right hemicolectomy, anterior resection or abdominoperineal resection) at the Auckland City Hospital. 2.Able to give informed consent. 3.Able to undergo the clinical and cognitive assessments 4.Able to tolerate a post-operative MRI brain scan.

Exclusion Criteria

1.Previous neurological disease, including stroke or transient ischemia attack (TIA), or cognitive impairment as determined by Abbreviated Mental Test Score (AMT<7), or past psychiatric disease that would interfere with the interpretation of clinical and radiological data.
2.Contraindications to MRI brain scanning including permanent pacemaker/implantable defibrillator, metallic foreign bodies, claustrophobia.
3.Any patient that the assessing clinician or treating surgeon or anaesthetist does not believe would be an appropriate candidate for the study.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of new ischemic change on post-operative MRI brain scans with DWI in patients undergoing bowel surgery.[The MRI brain scans will be performed once the participant is clinically stable at 3-7 days following their operation.]

Secondary Outcome Measures

Name	Time	Method
Incidence of peri-operative stroke, transient ischemic attack and acute confusional state in bowel surgery patients.[Participants will undergo a clinical assessment at 3-7 days following their operation.]