Mechanisms of Change in Brief Treatment for Borderline Personality Disorder

Not Applicable

• Conditions: Borderline Personality Disorder
• Interventions: Behavioral: treatment as usual; Behavioral: Good Psychiatric Management - Brief

• Registration Number: NCT03717818
• Lead Sponsor: University of Lausanne Hospitals

Brief Summary

The present two-arm randomized controlled study aims at testing the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants undergo assessments at four points (intake, 2 months, discharge and 12 month follow-up). In addition to symptom measures, all individuals undergo a two-step assessment for the potential mechanisms of change (i.e., emotion and socio-cognitive processing): a) behavioural and b) neurofunctional. We hypothesize that change in the mechanisms explains the treatment effects. The present study uses an innovative treatment of BPD and at the same time a sophisticated assessment procedure to demonstrate the critical role of psychobiological change in emotion and sociocognitive processing in brief treatments. It will help increase the effectiveness of initial treatment phase for BPD and help diminish the societal burden of disease related with BPD. This study is funded by the Swiss National Science Foundation (SNSF).

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-10
• Study Start: 2018-10-19
• Study First Submitted: 2018-10-22
• Study First Submitted QC: 2018-10-22
• Last Update Submitted: 2018-10-23
• Study First Posted: 2018-10-24
• Last Update Posted: 2018-10-25
• Primary Completion: 2022-12
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Borderline Personality Disorder
• age between 18 and 35

Exclusion Criteria

• non-mastery in French
• neurological disorders
• schizophrenia (according to DSM-5)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment as Usual-Brief	treatment as usual	-
Good Psychiatric Management-Brief	Good Psychiatric Management - Brief	-

Primary Outcome Measures

Name	Time	Method
ZAN-BPD (Zanarini Borderline Personality Disorder Scale; Zanarini, 2003)	4 months	measures borderline symptomatology from an dimensional perspective, ranges between 0 and 36 (36 being the most symptomatic), global score (sum of all 9 items coded between 0 and 4) used.

Secondary Outcome Measures

Name	Time	Method
BSL-23 (Borderline Symptom List, Short Version; Bohus et al., 2009)	4 months	measures the intensity of borderline symptoms using a mean score of the 23 items ranging between 0 and 4 (4 being the most symptomatic), the mean score will be used.
OQ-45 (Outcome Questionnaire-45.2, Lambert et al., 2004)	4 months	measures the level of problems (distress, social and interpersonal) on a scale ranging from 0 to 180 (45 items coded between 0 and 4, 4 being the most symptomatic). A total sum score will be used

Trial Locations

Locations (1)

Department of Psychiatry-CHUV, University of Lausanne; 🇨🇭 Lausanne, VD, Switzerland