A study of emotional responsiveness and apathy in Parkinson*s disease

Completed

• Conditions: parkinson's disease; emotional response; 10028037

• Registration Number: NL-OMON34379
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Inclusion criteria for PD patients are:
-Idiopathic Parkinson*s disease according to the Queen Square Brain Bank criteria (De Rijk, Rocca et al, 1997).
-The use of a stable dose of antiparkinsonian medication.
-Signed informed consent;Inclusion criteria for healthy controls are:
-signed informed consent

Exclusion Criteria

Exclusion criteria for PD patients are:
-patients with other neurodegenerative disorders other than PD
-Major Depressive Disorder as defined by the criteria of the fourth edition of the Diagnostic and Statistical Manual (DSM-IV) of the American Psychiatric Association (APA) (American Psychiatric Association 1994).
-cognitive deterioration operationalised as a score of <26 on the Mini Mental State Examination (MMSE) (Folstein, Folstein et al. 1975) or fulfilling diagnostic criteria for Parkinson*s Disease Dementia (PDD) (Dubois, Burn et al. 2007).
-use of psychopharmacological medication, with the exception of benzodiazepines
-abuse of alcohol and/or drugs
-exclusion criteria for MRI scanning;Exclusion criteria for healthy controls are:
-neurodegenerative disorders
-Major Depressive Disorder as defined by the criteria of the fourth edition of the Diagnostic and Statistical Manual (DSM-IV) of the American Psychiatric Association (APA) (American Psychiatric Association 1994).
-cognitive deterioration operationalised as a score of <26 on the Mini Mental State Examination (MMSE) (Folstein, Folstein et al. 1975) or fulfilling diagnostic criteria for Parkinson*s Disease Dementia (PDD) (Dubois, Burn et al. 2007).
-use of psychopharmacological medication, with the exception of benzodiazepines
-abuse of alcohol and/or drugs

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In this study the main parameters is emotional responsiveness measured on a<br /><br>visual analogue (VAS) scale.<br /><br>. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Physical concomitants of emotional responsiveness: heart rate, blood pressure,<br /><br>skin conductance and pupil width<br /><br>Salivary cortisol levels will be measured at the beginning of the study and<br /><br>after emotional pictures are viewed.<br /><br>Performance on neuropsychiatric and neuropsychological questionnaires and tests</p><br>