Central venous blood gas and cardiac output

Not Applicable

Completed

• Conditions: Sepsis; Infections and Infestations

• Registration Number: ISRCTN60931121
• Lead Sponsor: James Cook University Hospital (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2011-10-01
• Study Start: 2012-01-24
• Last Update Posted: 26 March 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. 28 Adult patients (>18 years old)
2. Have severe sepsis or septic shock, as defined by the International Sepsis Definitions Conference (Levy MM et al, 2003)
3. Are equipped with both arterial and central line
4. In whom CO monitoring and an intervention to increase stroke volume (SV) and hence CO (e.g. fluid bolus, inotropes) is deemed necessary

Exclusion Criteria

1. No consent: objection from somebody close who is willing to be consulted about the appropriateness of the patient being enrolled in the study in line with the Mental Capacity Act objection through registered lasting power of attorney for medical affairs advance ecision precluding research retrospective withdrawal of consent
2. Pregnancy
3. Age below 18 years

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The correlation between changes of cardiac output with changes in central venous saturation and central venous arterial partial pressure of carbon dioxide difference, respectively

Secondary Outcome Measures

Name	Time	Method
Sensitivity and specificity of pulse pressure and stroke volume variation to predict an increase in cardiac output by at least 10%