Comparison of Inflammation, Oxidative Stress, and Respiratory Outcomes Between Conventional and Protective One Lung Ventilation in Patients Undergoing Lung Resection Surgery

Not Applicable

Completed

• Conditions: lung cancer; lung lobectomy; Cancer - Lung - Non small cell; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12610000477022
• Lead Sponsor: Jie Ae Kim

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-06-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

American Society of Anesthesiologist (ASA) physical status 1-2 and scheduled for an elective video-assisted thoracoscopic (VATS) lobectomy due to lung cancer

Exclusion Criteria

patient’s refusal to take part in the study, coexisting chronic obstructive lung disease with forced expiratory volume in 1 s of less than 80% of predicted and/or forced expiratory volume in 1 s over forced vital capacity ratio of less than 0.7, chronic renal failure, altered liver function, preoperative corticosteroid treatment during one month before operation, elevated temperature or leukocyte count, or any new pulmonary infiltration on the chest radiography (CXR).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood interleukin 6[baseline = baseline time after anesthetic induction and before ventilation strategy application; OLV 60 = 60 minutes after initiation of OLV; TLV 15 = 15 minutes after the end of OLV];respiratory parameters(airway pressure, tidal volume, inspiratory oxygen partial pressure:FiO2, respiratory rate) measured by pneumotachometer[baseline = baseline time after anesthetic induction and before ventilation strategy application; OLV 15 and OLV 60 = 15 minutes and 60 minutes after initiation of OLV, respectively; two lung ventilation(TLV) 15 = 15 minutes after the end of OLV];arterial blood gas analysis: arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbondioxide (PaCO2), pH[baseline = baseline time after anesthetic induction and before ventilation strategy application; OLV 15 and OLV 60 = 15 minutes and 60 minutes after initiation of OLV, respectively; TLV 15 = 15 minutes after the end of OLV]

Secondary Outcome Measures

Name	Time	Method
blood malondialdehyde[baseline = baseline time after anesthetic induction and before ventilation strategy application; OLV 60 = 60 minutes after initiation of OLV; TLV 15 = 15 minutes after the end of OLV];hospital stay through data linkage to patient medical records[when patients' discharge];chest radiograph[every day for 1 week postoperatively]