Alterations in Cerebellar-dependent Adaptation Due to Cannabis Use Measured With an Explicit-implicit Visuo-motor Learning Paradigm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 主要终点
- Directional error of hand trajectories towards a target
研究概览
简要总结
The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria.
- •Patients screen positive to cannabis in the urine analysis performed a week prior to assessment.
- •Right-handed patients.
- •Patients provide a signed consent.
排除标准
- •Patients with another current substance use disorder (with the exception of tobacco).
- •Patients with a visual impairment that has not been corrected.
- •Patients with a cognitive impairment such as mental retardation.
- •Patients with psychotic disorders.
研究组 & 干预措施
Experimental Explicit
Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
干预措施: Visuo-motor rotation (Behavioral)
Experimental Explicit
Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
干预措施: Explicit strategy (Behavioral)
Control Explicit
Healthy subject performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
干预措施: Visuo-motor rotation (Behavioral)
Experimental Implicit
Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy
干预措施: Visuo-motor rotation (Behavioral)
Experimental Implicit
Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy
干预措施: Explicit strategy (Behavioral)
Control Implicit
Healthy subject performs visuo-motor rotation tasks without being informed of the explicit strategy
干预措施: Visuo-motor rotation (Behavioral)
结局指标
主要结局
Directional error of hand trajectories towards a target
时间窗: 1 day (a single session)
次要结局
- Intrinsic Motivational Inventory(1 day (a single session))
- Reaction times(1 day (a single session))
研究者
Paul Verschure
Professor
Universitat Pompeu Fabra