Neural Indices Associated With Relapse in Cannabis Dependence

• Conditions: Cannabis Dependence

• Registration Number: NCT02801422
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired stress regulation. Therefore, neural markers of brain processes underlying the beforementioned components will be studied. Subsequent follow-up drug use interviews will reveal associations between relapse in cannabis dependence and alterations in brain networks of cognitive control, craving and stress.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02
• Study First Submitted: 2016-06-11
• Study First Submitted QC: 2016-06-11
• Study First Posted: 2016-06-15
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-26
• Last Update Posted: 2018-10-29
• Primary Completion: 2019-03
• Study Completion: 2019-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Cannabis Dependence
• 24 hours abstinence

Exclusion Criteria

• other DSM-4 diagnosis
• neurological disorder

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
fMRI neural activation patterns of emotional processing	one time point = fMRI assessment after minimum 24 hours of abstinence	Activation patterns associated with emotion processing, emotion regulation, craving and stress are determined in addicted cannabis users compared to non-using matched control subjects

Secondary Outcome Measures

Name	Time	Method
Timeline Followback Interviews	one time point = 12 months after fMRI data acquisition	Association between fMRI correlates and drug use during follow up preiod as predictor for relapse

Trial Locations

Locations (1)

University of Bonn; 🇩🇪 Bonn, North Rhine Westfalia, Germany