The effect of sevoflurane on the corrected QT interval (QTc), QTc dispersion, the interval between peak to end of T wave (Tp-e) and Tp-e/QTc ratio in diabetic and non diabetic women undergoing elective non-laparoscopic surgery requiring general anaesthesia with endotracheal intubation

The Queen Elizabeth Hospital0 个研究点目标入组 40 人开始时间: 2010年3月30日最近更新: 2021年11月29日

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•Women aged > 40 yr ASA I – III (American society of Anesthesiologists physical status) scheduled for elective non-laparoscopic surgical procedures lasting more than 60 min requiring general anaesthesia with endotracheal intubation would be recruited in this study. Medically managed (both oral hypoglycaemic agents and insulin) diabetic patients with the duration of the disease for atleast two years or those who have atleast one HbA1c (glycosylated haemoglobin) level more than 7% recorded prior to the presentation would be compared with a control group of non diabetic patients.

•Patients with a preoperative QTc interval greater than 440ms, having conduction defects and arrhythmias, taking medications affecting the QTc interval , suffering from ischemic heart disease as defined by previous history of angina, myocardial infarction or ischaemic cardiomyopathy, patients with congenital or acquired cardiac defects, preexisting electrolyte imbalances and thyroid and renal dysfunction as defined by the estimated glomerular filtration rate (eGFR) < 60 ml/min/ 1.73m 2 would be excluded. Diabetic patients on diet control and patients with known or suspected family history of malignant hyperthermia would also be excluded

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