The Effects of Sevoflurane and Desflurane on QT Interval Measured With Cardiac Electrophysiological Balance Index

Not Applicable

• Conditions: Sevoflurane; Desflurane; QT Interval; Electrophysiological Balance Index
• Interventions: Diagnostic Test: 12- derivation Electrocardiography

• Registration Number: NCT05225779
• Lead Sponsor: Ankara City Hospital Bilkent

Brief Summary

The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-01-05
• Status Verified: 2022-02
• Study Start: 2022-02
• Study First Submitted QC: 2022-02-02
• Last Update Submitted: 2022-02-02
• Study First Posted: 2022-02-07
• Last Update Posted: 2022-02-07
• Primary Completion: 2022-05
• Study Completion: 2022-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. ASA I-II-III risk group
2. the operation time is longer than 1 hour in the Urology department.

Exclusion Criteria

1. bundle branch block in preoperative ECG,
2. Non-sinus heart rhythm,
3. QT length in preoperative ECG,
4. using drugs that cause known QT prolongation ( beta-blocker drugs using will be included),
5. development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period,
6. patients with electrolyte disorders,
7. patient refusal -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane	12- derivation Electrocardiography	General Anesthesia procedure with sevoflurane
desflurane	12- derivation Electrocardiography	General Anesthesia procedure with desflurane

Primary Outcome Measures

Name	Time	Method
QTc T4	During surgery (at the time of MAC reached 1,3)	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1,3 , it will be calculated from the ECG.
QTc T5	During surgery (at the time of MAC reduced 0,3)	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reduces 0,3, it will be calculated from the ECG.
iCEB T4	During surgery (at the time of MAC reached 1,3)	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG.
QTc T3	During surgery (at the time of MAC reached1)	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1, it will be calculated from the ECG.
iCEB T0	Baseline, preoperative	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
iCEB T1	During surgery (at the time of the anesthesia induction)	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
iCEB T2	During surgery (at the time of MAC reached 0,6)	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG.
QTc T0	Baseline, preoperative	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).
iCEB T5	During surgery (at the time of MAC reduced 0,3)	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG.
QTc T1	During surgery (at the time of the anesthesia induction)	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).
QTc T2	During surgery (at the time of MAC reached 0,6)	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 0,6, it will be calculated from the ECG.
iCEB T3	During surgery (at the time of MAC reached 1)	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG.