A Prospective Randomized Comparison of the Effects of Sevoflurane and Desflurane Anesthesia on QT Interval Measured With Cardiac Electrophysiological Balance Index
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 主要终点
- QTc T4
研究概览
简要总结
The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-II-III risk group
- •the operation time is longer than 1 hour in the Urology department.
排除标准
- •bundle branch block in preoperative ECG,
- •Non-sinus heart rhythm,
- •QT length in preoperative ECG,
- •using drugs that cause known QT prolongation ( beta-blocker drugs using will be included),
- •development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period,
- •patients with electrolyte disorders,
- •patient refusal -
结局指标
主要结局
QTc T4
时间窗: During surgery (at the time of MAC reached 1,3)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1,3 , it will be calculated from the ECG.
QTc T5
时间窗: During surgery (at the time of MAC reduced 0,3)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reduces 0,3, it will be calculated from the ECG.
iCEB T4
时间窗: During surgery (at the time of MAC reached 1,3)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG.
QTc T3
时间窗: During surgery (at the time of MAC reached1)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1, it will be calculated from the ECG.
iCEB T0
时间窗: Baseline, preoperative
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
iCEB T1
时间窗: During surgery (at the time of the anesthesia induction)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
iCEB T2
时间窗: During surgery (at the time of MAC reached 0,6)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG.
QTc T0
时间窗: Baseline, preoperative
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).
iCEB T5
时间窗: During surgery (at the time of MAC reduced 0,3)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG.
QTc T1
时间窗: During surgery (at the time of the anesthesia induction)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).
QTc T2
时间窗: During surgery (at the time of MAC reached 0,6)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 0,6, it will be calculated from the ECG.
iCEB T3
时间窗: During surgery (at the time of MAC reached 1)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG.
次要结局
未报告次要终点
研究者
Işıl Karabeyoğlu
principal investigator
Ankara City Hospital Bilkent