Two Different Preparations of Sevoflurane in Induction

Phase 4

Completed

• Conditions: Coughing on Induction; Vapors; Inhalation
• Interventions: Drug: Sevoflurane

• Registration Number: NCT01792063
• Lead Sponsor: Istanbul University

Brief Summary

In our study we aim to study the effects of two preparations of Sevoflurane in vital capacity rapid inhalation induction.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02
• Study First Submitted: 2013-02-12
• Study First Submitted QC: 2013-02-14
• Study First Posted: 2013-02-15
• Status Verified: 2013-04
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Last Update Submitted: 2013-04-18
• Last Update Posted: 2013-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients undergoing abdominal surgery

Exclusion Criteria

• Patients with any cardiovascular or respiratory disease, usage of any kind of sedative drug, expected airway difficulty and obese patients (BMI>35) will be excluded from the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sevoflurane B	Sevoflurane	Orginal sevoflurane
Sevoflurane A	Sevoflurane	Generic sevoflurane

Primary Outcome Measures

Name	Time	Method
effect of different preparations of sevoflurane on Induction on hypnosis time	1 hour	Induction for anesthesia will be achieved with sevoflurane A and Sevoflurane B in total of 100 randomized (American Society of Anesthesiology status I-II) patients undergoing abdominal surgery. During the induction patients will be asked to breath as deep as possible and then hold their breaths to the point where they cannot anymore and flexing their right arm. Occurrence of hypnosis will be confirmed with both the loss of eyelash-reflex and failing of flexed-holding arm. Time and number of breaths needed for the loss of consciousness will be noted. Existence of hiccup, cough, increase in secretions, and refusal of the mask by the patient will be reported if any. All patients will be extubated and released to the ward after they are questioned about any discomfort or issue they want to report to anesthesiologist

Secondary Outcome Measures

Name	Time	Method
effect of different sevoflurane preparations on hemodynamics	1 hour	After the induction and occurrence of hypnosis, Systemic arterial pressure (SAP) values will be noted. Tracheal intubation will be performed and post-intubation SAP values will be noted. The SAP values will noted in the 5th minute of the induction.

Trial Locations

Locations (1)

Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department; 🇹🇷 Istanbul, Fatih, Turkey