The Effect of Ketone Esters on Forearm Glucose Metabolism

Not Applicable

Not yet recruiting

• Conditions: Healthy

• Registration Number: NCT06685913
• Lead Sponsor: University of Exeter

Brief Summary

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.

Detailed Description

Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.

Study Timeline

• Status Verified: 2024-11
• Study Start: 2024-11-11
• Study First Submitted: 2024-11-11
• Study First Submitted QC: 2024-11-11
• Last Update Submitted: 2024-11-11
• Study First Posted: 2024-11-13
• Last Update Posted: 2024-11-13
• Primary Completion: 2025-12-31
• Study Completion: 2034-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Age 18-40

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Exclusion Criteria

• Any diagnosed metabolic health condition
• Pregnant
• Smoker
• Diagnosed Cardiovascular disease
• Use of medications deemed by research team to affect study outcomes
• Recent history of musculoskeletal injury
• Aged >40 or <18
• Allergy to ingredients in the supplement, including ketones, lactose or milk protein

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Forearm glucose net balance	3 hours	Net balance of blood glucose across a forearm following a mixed meal tolerance test

Secondary Outcome Measures

Name	Time	Method
Forearm amino acid net balance	3 hours	Net balance of blood amino acids across a forearm following a mixed meal tolerance test
Serum insulin concentrations	3 hours	Insulin concentration using ELISA assay over 4 and 8 hours following a meal
Ketone concentration	3 hours	Ketone concentration using colorimetric assay over 4 and 8 hours following a meal
Forearm non-esterified fatty acid net balance	3 hours	Net balance of blood non-esterified fatty acids across a forearm after a mixed meal tolerance test

Trial Locations

Locations (1)

Nutritional Physiology Research Unit, University of Exeter; 🇬🇧 Exeter, Devon, United Kingdom