NCT06324669已完成不适用
Investigating the Blood Glucose Lowering Effect of Exogenous Ketone Ingestion in People With Type 2 Diabetes
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Rate of endogenous glucose production
研究概览
简要总结
Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important in the treatment of type 2 diabetes (T2D). The purpose of this research is to determine if a ketone drink can lower blood sugar in people with T2D following a meal. This research will provide new knowledge about the regulation of blood sugar. This may also inform if ketone drinks could be used as a treatment for T2D.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
Coded, known only to independent individual
入排标准
- 年龄范围
- 41 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 41-70 years old
- •Body mass index 27-40 mg/m²
- •Type 2 diagnosis for more than 1 year
排除标准
- •Currently following ketogenic diet
- •Use of insulin
- •HbA1c >10%
- •Recent weight loss (>5kg in 6 months)
- •Recent eGFR <30mL/min
- •Heart failure
- •Substance abuse
- •Myocardial infarction within 6 months
- •Pregnancy or consideration of
- •Use of antipsychotic drugs
结局指标
主要结局
Rate of endogenous glucose production
时间窗: 4 hours
Rate of endogenous glucose production over 4 hours in response to a meal measured by blood sample
次要结局
- Insulin concentration(4 and 8 hours)
- Beta-cell function(4 and 8 hours)
- GLP-1 concentration(4 and 8 hours)
- Glucagon concentration(4 and 8 hours)
- Free fatty acid concentration(4 and 8 hours)
- Exogenous glucose rate of appearance(4 and 8 hours)
- Total rate of glucose disappearance(4 and 8 hours)
- Rate of gluconeogenesis(4 and 8 hours)
- Rate of glycogenolysis(4 and 8 hours)
- GIP concentration(4 and 8 hours)
- Glycerol concentration(4 and 8 hours)
- Ketone concentration(4 and 8 hours)
- Energy expenditure(4 and 8 hours)
- Total rate of glucose appearance(4 and 8 hours)
研究者
研究点 (2)
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