Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure

Recruiting

• Conditions: Acute Respiratory Failure

• Registration Number: NCT03826797
• Lead Sponsor: University of Modena and Reggio Emilia

Brief Summary

This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure of different etiology (including COVID-19).

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10-16
• Study First Submitted: 2019-01-28
• Study First Submitted QC: 2019-01-30
• Study First Posted: 2019-02-01
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-22
• Last Update Posted: 2023-03-23
• Primary Completion: 2024-02-28
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Age >18 years
• Acute hypoxic respiratory failure (P/F < 200)

Exclusion Criteria

• Acute pulmonary edema
• Chest wall deformities
• Immediate need for Mechanical Ventilation
• Pregnancy
• Hypercapnic RF

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Esophageal pressure impact on non invasive respiratory support (NRS) failure	24 hours	Correlation between esophageal pressure values within 24 hours from NRS start and NRS failure

Secondary Outcome Measures

Name	Time	Method
Dynamic compliance impact on NRS failure	24 hours	Correlation between dynamic compliance values within 24 hours from NRS start and NRS failure
Transpulmonary pressure impact on NRS failure	24 hours	Correlation between transpulmonary pressure values within 24 hours from NRS start and NRS failure
Dynamic mechanical power impact on NRS failure	24 hours	Correlation between dynamic mechanical power within 24 hours from NRS start and NRS failure
Pnose impact on NRS failure	24 hours	Correlation between Pnose within 24 hours from NRS start and NRS failure
Correlation between nasal pressure (Pnose) and esophageal pressure	24 hours	Correlation between nasal pressure (Pnose) and esophageal pressure

Trial Locations

Locations (1)

University Hospital of Modena Policlinico; 🇮🇹 Modena, Italy