The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation

Phase 4

• Conditions: ARDS; Intra-abdominal Hypertension

• Registration Number: NCT01825304
• Lead Sponsor: Nanjing Medical University

Brief Summary

Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-10
• Study Start: 2011-10
• Primary Completion: 2012-12
• Study First Submitted: 2013-04-02
• Study First Submitted QC: 2013-04-04
• Last Update Submitted: 2013-04-04
• Study First Posted: 2013-04-05
• Last Update Posted: 2013-04-05
• Study Completion: 2013-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• intra-abdominal hypertension
• mechanical ventilation
• sedation

Exclusion Criteria

• underlying pulmonary disease
• age older than 60 years and younger than 18 years
• vital signs were not stable
• non voluntary

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
ventilator-free days	28d	Comparison of two groups the duration of ventilation-free in 28d,ventilator-free day include weaning from mechanical ventilation more than 24h.

Secondary Outcome Measures

Name	Time	Method
mortality	28d	28-Day mortality include patients who giving up treatment due to critical condition

Trial Locations

Locations (1)

Ventilator; 🇨🇭 Bern, Switzerland