the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- ARDS
- Sponsor
- Nanjing Medical University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- ventilator-free days
- Last Updated
- 13 years ago
Overview
Brief Summary
Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.
Investigators
Gang Li
PLA Research Institute of general surgery
Nanjing Medical University
Eligibility Criteria
Inclusion Criteria
- •intra-abdominal hypertension
- •mechanical ventilation
Exclusion Criteria
- •underlying pulmonary disease
- •age older than 60 years and younger than 18 years
- •vital signs were not stable
- •non voluntary
Outcomes
Primary Outcomes
ventilator-free days
Time Frame: 28d
Comparison of two groups the duration of ventilation-free in 28d,ventilator-free day include weaning from mechanical ventilation more than 24h.
Secondary Outcomes
- mortality(28d)