Pilot Study of Low-Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock

Yale University1 site in 1 countryJanuary 8, 2018

ConditionsBacterial Sepsis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Bacterial Sepsis
Sponsor: Yale University
Locations: 1
Primary Endpoint: Length of stay (LOS) in the ICU.
Status: Withdrawn
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This pilot study aims to test the tolerability of low-carbohydrate enteral nutrition in patients with bacterial septic shock.

Detailed Description

This study seeks to assess the tolerability of utilizing low-carbohydrate nutrition in patients admitted to the MICU with bacterial septic shock. Low carbohydrate feeds have been used before in the critical care setting and were well-tolerated.

Registry

clinicaltrials.gov

Start Date

January 8, 2018

End Date

June 2022

Last Updated

4 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Yale University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients aged 18-65 admitted to the MICU with a diagnosis of severe sepsis or septic shock
•Patients with 35 \> BMI \> 18.5
•Patients with serum pro-calcitonin \> 1 ng/mL in the first 24 hours of hospitalization

Exclusion Criteria

•Patients with chronic kidney disease as defined by glomerular filtration rate \< 60 for \> 6 months
•Patients with chronic liver disease as defined by radiographic or tissue evidence of cirrhosis or persistently abnormal liver function tests for \> 6 months
•Patients with current malignancies
•Patients with autoimmune disease on current immunotherapy
•Patients on corticosteroids at doses of prednisone or prednisone-equivalents \> 5 mg for \> 6 months
•Patients with weight-reduction surgeries
•Patients with positive viral studies in the first 24 hours of admission