Evaluation of the effect of targeted mild therapeutic hypercapnia during and after cardiopulmonary bypass on cerebral oxygenation and neuropsychological outcomes
Not Applicable
Completed
- Conditions
- Cardiac surgeryLow cerebral oxygenationCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12616000111471
- Lead Sponsor
- Austin Health
- Brief Summary
Trend towards benefit of targeted mild therapeutic hypercapnia (slightly higher than normal targeting of blood carbon dioxide level) on cerebral oxygenation during cardiopulmonary bypass; non-inferior safety outcomes of intervention; finding of ongoing cerebral oxygen desaturation post-operatively across both intervention & control groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 31
Inclusion Criteria
1. Admitted to the Austin Hospital for elective cardiac surgery
2. Aged 18 years or older
3. Able to speak and read English
Exclusion Criteria
1. Pre-operative Mini-Mental State Examination score < 24
2. Emergency cases
3. History of neuropsychiatric disorders
4. Contraindications to increased CO2 levels, such as right-sided heart failure, pulmonary hypertension, metabolic acidosis
5. Aortic arch surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebral oxygenation as measured by Near-Infrared Spectroscopy[Five-minutely over the course of the surgery, fifteen-minutely over the 12 hours post-operatively, and continuously for a period of five minutes on days 2 and 3 post-operatively]
- Secondary Outcome Measures
Name Time Method