Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

Not Applicable

Completed

• Conditions: Hypercapnia
• Interventions: Device: high flow nasal canula

• Registration Number: NCT05948527
• Lead Sponsor: Mansoura University

Brief Summary

Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Status Verified: 2023-06
• Study First Submitted: 2023-06-24
• Primary Completion: 2023-07-01
• Study Completion: 2023-07-01
• Study First Submitted QC: 2023-07-13
• Last Update Submitted: 2023-07-13
• Study First Posted: 2023-07-17
• Last Update Posted: 2023-07-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients with mild Hypercapnia

Exclusion Criteria

• Excluded cases had age less than 18 years or pediatric group .
• patients with their mental state altered, confused, comatose, severe agitation or non cooperative
• Cases with moderate or severe Hypercapnia
• cases in need for immediate invasive mechanical ventilation
• cases with respiratory rate more than 35 breath per minute.
• cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles
• Shock , hemodynamic instability, post arrest cases,
• cases with facial trauma or severe nasal deformity,
• Patients with sleep breathing disorders or upper airway obstruction
• patients with history of home ventilation prior admission

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30)	high flow nasal canula	with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disorders

Primary Outcome Measures

Name	Time	Method
Arterial Blood Gases changes	48 hours	The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission.

Secondary Outcome Measures

Name	Time	Method
Number of participants in need for ventilation	7 days	Secondary outcome was concerned about need to non invasive mechanical ventilation or invasive mechanical ventilation.

Trial Locations

Locations (1)

Mansoura University Hospitals; 🇪🇬 Mansoura, Dakahlia Governorate, Egypt