A phase III multi-centre randomised controlled trial to evaluate the ability of slightly higher than normal carbon dioxide levels, compared to normal carbon dioxide levels, to reduce brain damage in resuscitated cardiac arrest patients admitted to the intensive care unit.

Not Applicable

Completed

• Conditions: Out-of-hospital cardiac arrest; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12617000036314
• Lead Sponsor: A/Prof Glenn Eastwood

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-01-10
• Study Completion: 2022-03-29
• Last Update Posted: 26 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1700

Inclusion Criteria

Adult (greater than or equal to 18 years of age)
Out-of-hospital cardiac arrest of a presumed cardiac or unknown cause
Sustained return of spontaneous circulation - defined as 20 minutes with signs of circulation without the need for chest compressions
Unconscious (FOUR-score motor response of less than 4, not able to obey veral commands after sustained return of spontaenous circulation
Eligible for intensive care without restrictions or limitations
Within less than 180 minutes of return of spontaneous circulation

Exclusion Criteria

Unwitnessed cardiac arrest with an initial rhythm of asystole
Temperature on admission of less than 30oC
On extracorporeal membrane oxygenation prior to return of spontaneous circiulation
Obvious or suspected pregnancy
Intracranial bleeding
Severe chronic obstructive pulmonary disorder (COPD) with long-term home oxygen therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified