A pilot investigation of the efficacy of botulinum toxin Type A injection as an adjunct to the non-surgical treatment of chronic tennis elbow.
- Conditions
- Chronic lateral epicondylitisMusculoskeletal - Other muscular and skeletal disorders
- Registration Number
- ACTRN12605000774628
- Lead Sponsor
- Dr BJ Singer, School of Surgery and Pathology, The University of Western AustraliaMedical Research Foundation Building, Level 2, Rear 50 Murray Street, Perth, WA 6000
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Stopped early
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Diagnosis of 'tennis elbow' (pain over lateral epicondyle, increased by forceful gripping, resisted wrist extension- Symptoms for >6 months duration, not responded to conservative management (physiotherapy, bracing, splinting, steroid injection)- Males and non pregnant females.
Exclusion Criteria
Previous BTXA injection within 3 months or any history of adverse reaction to BTXA- Disorders producing disturbed neuromuscular transmission (eg: myasthenia gravis)- Concurrent use of aminoglycosides [potential sensitiser to effect of BTXA]- Active Rheumatoid arthritis involving the upper extremity - Previous elbow surgery or nerve entrapment of the affected extremity- Workers Compensation or other compensable patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean change in pain free grip strength post-injection compared to average of three baseline measures.[At 12 weeks post-injection (Jamar hand held dynomometer)]
- Secondary Outcome Measures
Name Time Method Change in maximal wrist isometric (dynamometer) elbow related pain and disability (Disability of Arm, Shoulder and Hand Scale - DASH)[At 6, 12,18, 24 weeks compared to average of three baseline measures.];Change in signal intensity on T1 and T2 weighted MR images.[At 12 weeks compared to a baseline MRI.]