Brown adipose tissue activity and thyroid hormone
- Conditions
- brown adipose tissuethyroid carcinoma1004373910003018
- Registration Number
- NL-OMON37371
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 18
- Male or postmenopausal females undergoing a total thyroidectomy for well-differentiated thyroid carcinoma
- Age 18-65 years
- Stable physical activity levels for at least six months
- Note: In case of use of anticoagulation, the dose will be adjusted according to plasma thyroid hormone values.
- Psychological unstable subjects (as judged by the treating medical specialist)
- Subjects with mental retardation (as judged by the treating medical specialist)
- Subjects with severe behavior disorders (as judged by the treating medical specialist)
- Pregnant subjects
- The use of the following medication is an exclusion criterium;
o ß-blockers
- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
- Abuse of drugs and/or alcohol
- Severe diabetes which requires application of insulin or patients with diabetes-related complications
- Patients that have donated blood in the past 6 months
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint of this study is the effect of thyroid hormone and<br /><br>thyroid-stimulating hormone on BAT activity in kBq and SUV. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints are the effects of thyroid hormone and thyroid-stimulating<br /><br>hormone on energy metabolism, body composotion, plasma values of thyroid<br /><br>hormone, body core temperature, skin surface temperature and skin perfusion. </p><br>