Establish the factors of predicting cognitive impairment and the effect of exercise intervention on cognitive function in patients with Parkinson’s disease

Not Applicable

• Conditions: Mild cognitive impairment in Parkinson' s disease; Mild cognitive impairment, Parkinson' s disease, Exercise, Cognitive function, Gait, Dual- task training

• Registration Number: TCTR20180530004
• Lead Sponsor: Mackay Medical College

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-30
• Study Completion: 2019-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Clinical diagnosis of idiopathic PD by a neurologist, Hoehn and Yahr stage I to III, independent walking,at least graduated from elementary school, medical stable, and no cognitive impairment (mini-mental state examination [MMSE] score ≥ 24).

Exclusion Criteria

Unstable medical conditions, dementia, drug addicts, tumor history within five years and other comorbid medical diseases known to interfere with participation in this study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
europsychological test pre-training, post-training, 3 months follow-up Paper-and-pencil test,quantitative EEG pre-training, post-training, 3 months follow-up Electroencephalograph, EEG,Gait performance pre-training, post-training, 3 months follow-up Single task walking and dual task walking

Secondary Outcome Measures

Name	Time	Method
Disease severity and clinical characteristics pre-training, post-training, 3 months follow-up Unified Parkinson's disease Rating Scale, UPDRS,Quality of life pre-training, post-training, 3 months follow-up Parkinson’s Disease Questionnaire, PDQ-8