Physical exercise for subtle memory problems
Not Applicable
- Conditions
- Mild Cognitive impairment, late onset Alzheimer disease.F06.7G30.1
- Registration Number
- RBR-5tv5vt
- Lead Sponsor
- niversidade de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Patients with mild cognitive impairment
Exclusion Criteria
Individuals with cognitive decline of sufficient intensity for the diagnosis of dementia will be excluded, as well as individuals with psychiatric disorders in activity (not in remission now). Other exclusion criteria include clinical illness or physical disability that prevents the achievement of aerobic exercise, auditory and visual impair cognitive assessment, scores on the questionnaire functionality Pfeffer greater than four and illiteracy. Here we characterize illiteracy to less than one year of formal education and inability to read the phrase Close your Eyes mini mental state examination.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expected outcome: changes in brain metabolism at rest state, in important regions for cognition. The results will be compared by paired t test, using values generated by positron emission tomography. The significance level considered was P <0.05.<br> ;Found outcome: In the analysis of the first 40 subjects, we found reduction in the resting metabolism of the rostral posterior cingulate cortex, bilaterally.
- Secondary Outcome Measures
Name Time Method Expected outcome: Improvement of cognitive measures obtained by neuropsychological assessment. Neuropsychological assessments are conducted by trained neuropsychologists. The results will be compared with the paired t-test and significance values stipulated in p <0.05.;Found outcome: In the analysis of the first 40 subjects, we found improvements on scales that measure: 1) Global cognition - ADAS-cog; 2) Visual memory - Wechsler Memory Scale - revised (WMS-R); 3) Visuospatial function - copy of the Rey-Osterrieth complex figure.