Chemoprotective effect of NAC on vancomycin induced nephrotoxicity
Not Applicable
- Conditions
- acute bactrial meningitis.Bacterial meningitis, unspecified
- Registration Number
- IRCT2013091814693N1
- Lead Sponsor
- Faculty of Pharmacy Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Filling consent form; Patients with diagnosis of acute bacterial meningitis who are candidated for receiving vancomycin; Age=16 yrs; Not receive vancomycin in last 2weeks Exclusion criteria: Clinical states which could change phahrmacokinetic of vancomycin (eg. burn, cystic fibrosis); Pregnancy; Patients with CKD who need dialysis ; Contraindication for vancomycin, treatment with other nephrotoxic agents.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum level of Cystatin-C. Timepoint: Baseline,5 and 10 days after treatment. Method of measurement: Turbidimetry.;Serum level of vancomycin. Timepoint: Baseline,5 and 10 days after treatment. Method of measurement: immunoassay technique,mcg/ml.
- Secondary Outcome Measures
Name Time Method Serum level of creatinine. Timepoint: every other days from begining of study. Method of measurement: jaffe method?mg/dl.