A double-blinded, randomised control trial to compare intraoperative morphine and methadone on the post-operative pain scores and analgesic requirements after shoulder arthroscopic surgery
- Conditions
- Post-operative painAnaesthesiology - Pain management
- Registration Number
- ACTRN12614001115628
- Lead Sponsor
- Dr Edwin Khoo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Consecutive patients admitted to Nepean Private Hospital during the study period who are undergoing shoulder arthroscopy
Able to give consent for procedure
ASA I-III
Chronic opiate use (taken opiates regularly in the month before procedure)
Opiate use in previous 48 hours
History of drug abuse
Psychiatric history
Age under 18 and over 85
Chronic renal failure (eGFR < 30mL/min/1.73m^2)
Chronic liver failure (cirrhosis/fulminant liver failure)
Weight >120kg
Allergies to study drugs (morphine/methadone)
Known contraindications to methadone (hypothyroidism, Addison’s disease, prostatic hypertrophy, urethral stricture)
Taking medications known to induce or inhibit cytochrome p450 (antifungals, macrolide antibiotics, SSRIs, antivirals)
Individuals known to be pregnant
Those who are not suitable for PCA
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference between total fentanyl PCA (patient-controlled analgesia) requirements. This is the total fentanyl requirements of participant after transfer from recovery and placed on PCA. This will be measured in micrograms.<br><br>[Discharge home (day 1 post-operatively)<br>]
- Secondary Outcome Measures
Name Time Method