Effect of Inspiratory Muscle Training in Cognition

Not Applicable

Recruiting

• Conditions: Mild Cognitive Impairment (MCI)

• Registration Number: NCT07146373
• Lead Sponsor: University of West Attica

Brief Summary

The goal of this clinical trial is to examine the effect of a respiratory muscle strengthening program on the cognitive and physical functioning of patients with neurocognitive disorders (Mild Cognitive Impairment) or those predisposed to them.

The main questions that aims to answer are:

1. Is Inpsiratory Muscle Training (IMT) feasible in people with mild cognitive impairement?

2. Could Inspiratory Muscle Training (IMT) improve congitive function in people with mild cognitive impairement?

3. Could Inspiratory Musclre training improve physical function in this population?

Participants will be:

1. \< 60 age or \> 90 age

2. MMSE (Mini Mental State Examination) score ≤ 28 and ≥ 18 and follow a high intensity IMT program along with a physical - cognitive program. or just the physical - cognitive program.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-03-01
• Status Verified: 2025-08
• Study First Submitted: 2025-08-21
• Study First Submitted QC: 2025-08-21
• Last Update Submitted: 2025-08-21
• Study First Posted: 2025-08-28
• Last Update Posted: 2025-08-28
• Primary Completion: 2027-12-30
• Study Completion: 2028-05-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• MMSE (Mini Mental State Examination) score ≤ 28 και ≥ 18
• stable treatment related to medication

Exclusion Criteria

• MMSE score < 18 και > 28
• psychological disorder
• any contraindication to physical training

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Mini Mental State Examination	T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up)

Secondary Outcome Measures

Name	Time	Method
Frontal Assessment Battery	T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up)
Addenbrooke's Cognitive Examination	T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up)
Time up and Go (TUG)	T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up)
Sit-to-Stand test	T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up)

Trial Locations

Locations (1)

University of West Attica; 🇬🇷 Aigáleo, Attica, Greece