Does platelet rich plasma help in early osteoarthritis knee? If so does more than one dose help more?

Not Applicable

Completed

• Conditions: Health Condition 1: null- Early osteoarthritis of knee

• Registration Number: CTRI/2017/04/008406
• Lead Sponsor: Sri Sathya Sai Institute of Higher Medical Sciences Prasanthigram

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-12-31
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

1)Grade 1, Grade 2 OA knee as per Kellgren - Lawrence radiographic staging.

2) Patients who give consent for treatment with platelet rich plasma as per our protocol.

3) Patients with stable knees, normal tibiofemoral alignment,or patellofemoral tracking.

Exclusion Criteria

1) Osteoarthritis secondary to joint inflammatory diseases (eg- rheumatoid arthritis, ankylosing spondylitis etc).

2)Patients with other diseases, affecting the knee joint like crystal arthropathy, symptomatic chondrocalcinosis, acute synovitis, excessive joint effusion( >100ml), cystic disease around the knee joint(eg-popliteal cyst).

3) Patients with generalized osteoarthritis.

4) Metabolic disease of the bone.

5) Patients with co-existing low back ache.

6) Late stages of osteoarthritis.

7) Intra articular injections within the previous three months.

8) Pertaining to platelet concentrate use - h/o thrombocytopenia, use of anticoagulant therapy, active infection, malignancies.

9) Patients with abnormal leucocyte count.

10) Patients with blood diseases, systemic metabolic, immunodeficiency state.

11) Local or generalised infection.

12)Varus-valgus malalignment above 5°, patellofemoral maltracking or untreated instability.

13)History of prior arthroscopic or surgical intervention of knee.

14) Treatment with corticosteroids < 3 months or medication < 7 days that could interfere with platelet aggregation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain assessment by Visual Analog SoreTimepoint: pretreatment and 3, 6 and 12 months

Secondary Outcome Measures

Name	Time	Method
Quality of life by International Knee Documentation Committee(IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Tegner Activity Level Scale <br/ ><br>Timepoint: pre treatment, 3, 6 and 12 months after treatment