A randomised controlled trial of therapist-assisted online psychological therapies for post-traumatic stress disorder

Not Applicable

Completed

• Conditions: Post-traumatic stress disorder; Mental and Behavioural Disorders

• Registration Number: ISRCTN16806208
• Lead Sponsor: niversity of Oxford

Brief Summary

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32326954/ (added 11/08/2022) 2023 Preprint results in https://dx.doi.org/10.2139/ssrn.4374584 (added 30/03/2023) 2023 Results article in https://doi.org/10.1016/s2215-0366(23)00181-5 (added 24/07/2023) 2024 Other publications in https://pubmed.ncbi.nlm.nih.gov/38554731/ Economic evaluation (added 03/04/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-05
• Study Completion: 2021-12-31
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 217

Inclusion Criteria

1. Aged 18 years and above
2. Diagnosis of Posttraumatic Stress Disorder (as assessed with the Structured Clinical Interview for DSM-5)
3. The current reexperiencing symptoms are linked to one or two discrete traumatic events experienced in adulthood.
Updated 05/11/2019: Their current reexperiencing symptoms are linked to one or two discrete traumatic events that they experienced in adulthood or adolescence, or several traumatic episodes during a longer period of high threat (e.g., domestic abuse, war zone experiences)
4. PTSD is the main psychological problem needing treatment
5. Willing and able to provide informed consent
6. Able to read and write in English
7. Access to internet
8. Willing to be randomly allocated to one of the psychological treatments or wait
9. If taking psychotropic medication, the dose must be stable for at least 1 month before randomisation
10. If currently receiving psychological therapy for PTSD, this treatment must have ended before randomisation

Exclusion Criteria

1. History of psychosis
2. Current substance dependence
3. Current borderline personality disorder
4. Acute serious suicide risk

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PTSD symptoms measured with PTSD Symptom Checklist 5 at baseline, 6, 13 weeks after random allocation (with follow-ups at 26, 39 and 65 weeks), and weekly during treatment