Effects of Recurrent PE on Women and Offspring

Not yet recruiting

• Conditions: Recurrence; Hypertension; Preeclampsia
• Interventions: Other: blood pressure,BMI, blood sample

• Registration Number: NCT05134285
• Lead Sponsor: Dunjin Chen

Brief Summary

The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.

Detailed Description

The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.

Study Timeline

• Status Verified: 2021-11
• Study First Submitted: 2021-11-08
• Study First Submitted QC: 2021-11-23
• Study First Posted: 2021-11-24
• Last Update Submitted: 2021-12-07
• Last Update Posted: 2021-12-08
• Study Start: 2022-01
• Primary Completion: 2024-11
• Study Completion: 2024-11

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 1000

Inclusion Criteria

• women with at least twice of delivery history

Exclusion Criteria

• women with chronic hypertension

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control	blood pressure,BMI, blood sample	pregnancy without preeclampsia
recurrent preeclampsia	blood pressure,BMI, blood sample	pregnancy complicated with preeclampsia at two deliveries
preeclampsia	blood pressure,BMI, blood sample	pregnancy complicated with preeclampsia at the first delivery or at the second delivery

Primary Outcome Measures

Name	Time	Method
level of FT3,FT4, and hTSH in blood	5 years after the second deliver	women
blood pressure and hypertension of women	5 years after the second deliver	blood pressure ≥140/90 mmHg
blood pressure and hypertension of offspring	5 years old	blood pressure≥140/90 mmHg
level of cholesterol, LDL, HDL, VLDL-C in blood	5 years after the second deliver	women
level of glycosylated hemoglobin in blood	5 years after the second deliver	women
level of AST and ALT in blood	5 years after the second deliver	women

Secondary Outcome Measures

Name	Time	Method
BMI of offspring	5 years old	weight(kg)/height(m)2
level of AI37℃、AI4℃、PRA、ALD、AngII in blood	5 years after the second deliver	women
level of fructosamine in blood	5 years after the second deliver	women
level of insulin in blood	5 years after the second deliver	women

Trial Locations

Locations (1)

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, China