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临床试验/CTRI/2025/03/083644
CTRI/2025/03/083644尚未招募1 期

A comparison of intraoperative VExUS score with central venous pressure and pulse pressure variation in guiding fluid management in patients undergoing valvular cardiac surgery: an interventional study

Sharek1 个研究点 分布在 1 个国家目标入组 41 人开始时间: 2025年7月4日最近更新:

试验速览

阶段
1 期
状态
尚未招募
发起方
入组人数
41
试验地点
1
主要终点
To determine that VExUS score is superior to pulse pressure variation and central venous pressure in determining fluid status intraoperatively.

研究概览

简要总结

Intraoperative fluid administration is a crucial element of anaesthesia management. While fluids may have beneficial effect, excessive fluid administration can lead to fluid buildup, which has been linked to negative side effects and subpar clinical results. Longer mechanical ventilation, renal failure, and possibly death are linked to fluid overload.[1,2]. Fluid buildup is a significant risk factor for extending mechanical ventilation, according to a 2020 prospective observational analysis by Da Silva SC et al. that included 496 patients undergoing coronary artery bypass graft (CABG).[3]Acute kidney injury (AKI) and positive fluid balance are correlated in patients undergoing general cardiac surgery; patients with zero fluid balance have the lowest risk of AKI. [4] In a multicenter randomized controlled research involving 171 patients, a statistically significant association was discovered between the use of diuretics and early ventilator weaning.[5] Therefore, especially in heart surgery, having zero or negative fluid balance before to extubation is essential.

Fast-track treatment in cardiac surgery refers to the use of anesthetic medicines that allow patients having cardiac surgery to discontinue mechanical ventilation quickly in the postoperative period.[6,7]According to current statistics, the earliest and safest time for fast tracking in cardiac surgery patients was within three hours after surgery.[8]Studies suggest that fast-track cardiac surgical management leads to better patient outcomes, shorter hospitalizations in the intensive care unit (ICU), shorter hospital stays, and lower health-care costs. Furthermore, several studies have found that the fast tracking does not increase the incidence of postoperative complications, death, or reintubation rates.

The Venous Excess Ultrasound Score (VExUS), a minimally invasive indicator of venous congestion, has gained popularity since its launch in 2020. By analyzing the inferior vena cava and hepatic and portal vein Doppler flow indices, the VExUS score assesses systemic congestion. This modality has a number of expanding and promising uses.

However, there are no reports of complete VExUS evaluations using transesophageal echocardiography (TEE), a technique frequently employed in cardiac surgery patients.

Consequently, the current study will look into how the VExUS score affects patients having single valve replacement surgeries in terms of fluid management.

研究设计

研究类型
Interventional

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Patients belonging to both genders of age group 18 to 65 years, NYHA grade one and two, Posted for elective single valve replacement i.e. Aortic or Mitral Valve replacement, Signed informed consent given by the patient.

排除标准

  • • Patient refusal • Double valve replacement patients • Redo surgery • Diagnosed heart failure patients.
  • • Patients contraindicated for esophageal echocardiography.

结局指标

主要结局

To determine that VExUS score is superior to pulse pressure variation and central venous pressure in determining fluid status intraoperatively.

时间窗: The outcome will be assessed on the day of surgery in one day

次要结局

  • 1. Improvement in fluid management & fluid homeostasis.(2. Prevents multi organ fluid congestion.)

研究者

发起方
Sharek
申办方类型
Government medical college

研究点 (1)

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