Effects of postoperative administration of celecoxib on postoperative pain management in patients after total knee arthroplasty. A randomized controlled study. - EPOCA

Mito medical center, Mito Kyodo General Hospital, University of Tsukuba0 个研究点目标入组 120 人开始时间: 2014年7月23日最近更新: 2023年10月17日

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•1) Patient who has a history or complication of hypersensitivity to celecoxib, fentanyl or sulfonamides, and patient who has a history or complication of a serious allergic reaction to any other drugs. 2) Patient who has a history or complication with aspirin-induced asthma. 3) Patient who has a complication of gastrointestinal hemorrhage or ulcer. 4) Patient who has severe hepatic dysfunction. 5) Patient who has severe renal dysfunction. 6) Patient who has severe cardiovascular dysfunction. 7) Patient who is in a perioperative period of coronary artery bypass surgery. 8) Patient who is pregnant, lactating or probably pregnant. 9) Patient who had a drug abuse. 10) Patient who takes or will take an analgetic drug or sleeping drug with the exception of the following drugs from two days before surgery to final evaluation. Ultrashort- acting Hypnotic including triazolam, zopiclone and zolpidem tartrate is permitted until surgery. 11) Patient who is judged not to carry the trial through by principal or co-investigator.

发起方

Mito medical center, Mito Kyodo General Hospital, University of Tsukuba