Positive Pressure and Gravity Affect Volumetric Capnography

Not Applicable

Completed

• Conditions: Hypoventilation
• Interventions: Other: body positions

• Registration Number: NCT03853057
• Lead Sponsor: Hospital Privado de Comunidad de Mar del Plata

Brief Summary

Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body positions on volumetric capnograms.

Detailed Description

In this interventional study awake and healthy volunteers will be submitted to spontaneous, pressure support and control pressure ventilation using a tight nasal mask. Volumetric capnography and electrical impedance tomography (EIT) will be continuously recorded during the protocol. Different body positions were randomly tested. Analysis of global and regional distribution of ventilation using EIT will be matched with changes observed in volumetric capnography-derived parameters.

Study Timeline

• Study First Submitted: 2015-03-03
• Status Verified: 2016-02
• Study Start: 2016-02-01
• Primary Completion: 2019-02-21
• Study Completion: 2019-02-21
• Study First Submitted QC: 2019-02-21
• Last Update Submitted: 2019-02-21
• Study First Posted: 2019-02-25
• Last Update Posted: 2019-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• American Society Anesthesia physical status I.
• Age between 25-39 years old,
• Body mass index between 23-28 kg/m2,
• Non-smokers.

Exclusion Criteria

• Presence of pulmonary or cardiac diseases.
• Abnormal spirometry.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
non-invasive ventilation	body positions	Non-invasive positive pressure at different body positions: sitting - supine - prone - right lateral and left lateral.

Primary Outcome Measures

Name	Time	Method
Analysis of the changes in volumetric capnographic parameters with changes in body positioning and positive pressure ventilation.	4 hours	The volunteers are breathing spontaneously with and without positive pressure support. Capnographic parameters were registered at each studied condition.

Secondary Outcome Measures

Name	Time	Method
Electrical impedance images of the distribution of ventilation with changes in body positioning and positive pressure ventilation.	4 hours	The volunteers are breathing spontaneously with and without positive pressure support. Electrical impedance images were taken at each studied condition.

Trial Locations

Locations (1)

Hospital Privado de Comunidad; 🇦🇷 Mar del Plata, Buenos Aires, Argentina