Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.

Phase 4

Completed

• Conditions: Diabetes Mellitus

• Registration Number: NCT00306696
• Lead Sponsor: GlaxoSmithKline

Brief Summary

Study examining the effect of different diuretics on fluid retention in diabetics treated with rosiglitazone.

Detailed Description

A randomised, open-label, parallel group study to evaluate the management of rosiglitazone-related fluid retention by investigating the effect of diuretics on plasma volume in subjects with type 2 diabetes mellitus treated for twelve weeks with rosiglitazone 4mg bd in addition to background anti-diabetic agents.

Study Timeline

• Study Start: 2002-10
• Study Completion: 2004-01
• Study First Submitted: 2006-03-22
• Study First Submitted QC: 2006-03-22
• Study First Posted: 2006-03-24
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-13
• Last Update Posted: 2016-09-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 388

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes in Haematocrit following 7 days diuretic adminstration.

Secondary Outcome Measures

Name	Time	Method
Total body fluid & extracellular fluid, body weight, haematocrit & haemoglobin.

Trial Locations

Locations (1)

GSK Investigational Site; 🇬🇧 London, United Kingdom