Impact of Branched-chain Amino Acids in the Development of Insulin Resistance
- Conditions
- Diabetes
- Interventions
- Dietary Supplement: Branched-chain amino acids reduced intake
- Registration Number
- NCT03261362
- Lead Sponsor
- German Diabetes Center
- Brief Summary
The purpose of this study is to clarify the role of the branched-chain amino acids in the development of Insulin resistance in patients with diabetes
- Detailed Description
The proposed project aims to elucidate the role of the BCAA in the development of insulin resistance and type 2 diabetes. The project tests the hypothesis that a diet induced decrease of BCAAs concentrations alter the metabolic mechanisms involved in the control insulin resistance and diabetes progression.
The specific aims are to elucidate the effect of the diet induced decrease of BCAAs concentrations on (I) peripheral and hepatic insulin sensitivity (II) ectopic fat distribution (III) energy metabolism (IV) metabolic and inflammatory status
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
- Diabetes type 2
- Non smokers
- Untrained
- Willingness to adhere to a diet intervention
- Chronic disease
- Pregnancy
- Cancer
- Antibiotic therapy
- Drug/alcohol abuse
- Competitive athletes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Amino acid powder with all amino acids Branched-chain amino acids reduced intake amino acid powder 80 g oral Administration 1 week Amino acid powder without BCAAs-reduced intake Branched-chain amino acids reduced intake Branched-chain amino acids reduced intake - amino acid powder lacking BCAAs 80 g oral Administration 1 week -
- Primary Outcome Measures
Name Time Method Clamp test up to 24 weeks Insulin sensitivity test
- Secondary Outcome Measures
Name Time Method Mixed Meal Test up to 24 weeks B cell function test
Trial Locations
- Locations (1)
German Diabetes Centre
🇩🇪Düsseldorf, Germany