Effects of Dynorphin 1-13 on Heroin Addiction - 1

Phase 2

Completed

• Conditions: Opioid-Related Disorders; Substance Withdrawal Syndrome

• Registration Number: NCT00000244
• Lead Sponsor: University of Minnesota

Brief Summary

The purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.

Detailed Description

Randomized double blinded study of the effects of a single IV dose of dynorphin A 1-13 on heroin withdrawal in human opiate addicts

Study Timeline

• Study Start: 1994-08
• Primary Completion: 1997-03
• Study Completion: 1997-03
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

opiate addict between the ages of 18-55

Exclusion Criteria

Regular abuse of other drugs, unstable medical conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Craving scale

Trial Locations

Locations (1)

U of Minnesota School of Medicine; 🇺🇸 Minneapolis, Minnesota, United States