Phacoemulsification and changes in outflow facility

Not Applicable

Completed

• Conditions: Glaucoma; outflow facility; phacoemulsification; Eye Diseases

• Registration Number: ISRCTN04247738
• Lead Sponsor: Guy's and St. Thomas' NHS Foundation Trust (UK)

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29654113

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-12-22
• Study Completion: 2012-10-01
• Last Update Posted: 21 May 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Aged greater than 21 years
2. Lens opacity deemed enough to be causing reduced vision
3. Diagnosis of primary open angle glaucoma (POAG) (Group 1) or no glaucoma (Group 2). POAG defined as glaucomatous optic neuropathy together with an intraocular pressure (IOP) greater than 21 mmHg on at least one occasion, visual field defects (using the 24-2 test pattern on a Humphrey Field Analyser) and a gonioscopic angle width of 3 or 4 and normal in appearance.
4. Patient's willingness to participate in the study and ability to give informed consent

Exclusion Criteria

1. Previous intraocular surgery
2. Previous ocular trauma that can cause damage to the drainage angle (e.g. angle recession)
3. International normalised ratio (INR) greater than 3.0 on the day of surgery (for the patients on warfarin)
4. Anterior segment neovascularisation
5. Chronic use of systemic or topical steroid
6. Any other concurrent ocular disease e.g. uveitis, diabetic retinopathy, corneal diseae, etc.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Outflow facility is measured using electronic Shiotz tonography at 3, 6 and 12 months post cataract surgery

Secondary Outcome Measures

Name	Time	Method
1. Anterior chamber depth is measured using IOL master at baseline<br>2. Intraocular pressure is measured using Goldmann applanation tonometer at baseline, 3, 6 and 12 months<br>3. Intra- or post-operative complications is measured using clinically intra-operatively and post operatively<br>4. Development of glaucoma is measured using clinically and Humphrey visual field at baseline and 12 months