Impedance Spectroscopy in Esophageal Cancer

Not Applicable

Completed

• Conditions: Cancer of Esophagus
• Interventions: Device: impedance

• Registration Number: NCT04046601
• Lead Sponsor: Sana Klinikum Offenbach

Brief Summary

Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection whereas advanced neoplasia might lead to an Operation of the esophagus. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and cancer can be sensed by electrical bioimpedance technique.

The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.

Detailed Description

Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection (ER) whereas advanced neoplasia might lead to esophagectomy. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and dysplasia can be sensed by electrical bioimpedance technique. The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.

Study Timeline

• Study First Submitted: 2019-08-04
• Study First Submitted QC: 2019-08-04
• Study First Posted: 2019-08-06
• Study Start: 2019-10-09
• Primary Completion: 2020-02-01
• Study Completion: 2020-02-15
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-13
• Last Update Posted: 2023-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

Known esophageal cancer and planned for endoscopic resection

Exclusion Criteria

1. Missing consent / agreement
2. Patient in bad condition for endoscopy or endoscopic resection
3. Patients with coagulopathy or anticoagulative medication which is a contraindication for endoscopy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Impedance	impedance	every resected tissue will measured by an impedance probe

Primary Outcome Measures

Name	Time	Method
impedance	10 min	value of 17 different frequencies in ohm

Secondary Outcome Measures

Name	Time	Method
differences in impedance	10 min	Differences in electrical impedance properties between different stages of early esophageal cancer.

Trial Locations

Locations (1)

Sana Clinic Offenbach; 🇩🇪 Offenbach, Hessen, Germany