Proteomics in early neoplasia in Barrett's esophagus: Biomarkers for early detection.
Recruiting
- Conditions
- Barrett's esophagus, Barrett's neoplasia, Barrett's cancer, Barrett's dysplasia, proteomics
- Registration Number
- NL-OMON22993
- Lead Sponsor
- Academic Medical Center (AMC), department of Hepato- and GastroenterologyErasmus Medical Center (EMC), department of Neurology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Inclusion criteria ‘dysplastic’ group:
1. Scheduled ER for Barrett’s esophagus containing HGD or early cancer;
Exclusion Criteria
Exclusion criteria ‘dysplastic’ group:
1. In case histopathological assessment of the frozen half of the ER specimen is necessary for clinical decision making, the specimen will be retrieved from the Barrett’s research tissue bank and further processed for clinical care.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of peptides and proteins which could indicate presence of early neoplasia in a Barrett's esophagus.
- Secondary Outcome Measures
Name Time Method 1. Number of identified proteins per cell-surface area;<br /><br>2. Differences and similarities between protein profiles of dysplastic vs non-dysplastic ER-samples in:<br>A. Epithelial cells;<br /><br>B. Stromal cells.