Diagnosis of Early Barrett's Neoplasia and Esophageal Squamous Cell Neoplasia by Electrical Impedance Spectroscopy in Human Tissue
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cancer of Esophagus
- Sponsor
- Sana Klinikum Offenbach
- Enrollment
- 67
- Locations
- 1
- Primary Endpoint
- impedance
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection whereas advanced neoplasia might lead to an Operation of the esophagus. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and cancer can be sensed by electrical bioimpedance technique.
The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.
Detailed Description
Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection (ER) whereas advanced neoplasia might lead to esophagectomy. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and dysplasia can be sensed by electrical bioimpedance technique. The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Known esophageal cancer and planned for endoscopic resection
Exclusion Criteria
- •Missing consent / agreement
- •Patient in bad condition for endoscopy or endoscopic resection
- •Patients with coagulopathy or anticoagulative medication which is a contraindication for endoscopy
Outcomes
Primary Outcomes
impedance
Time Frame: 10 min
value of 17 different frequencies in ohm
Secondary Outcomes
- differences in impedance(10 min)