octurnal Blood Pressure dipping re-establishment with Melatonin.
- Conditions
- Health Condition 1: I10- Essential (primary) hypertension
- Registration Number
- CTRI/2020/04/024768
- Lead Sponsor
- Centre for integrative Medicine and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients diagnosed with Hypertension.
On stable antihypertensive medication for 6 weeks before trial enrollment.
Non-dipping Blood pressure profile (>= 10% dipping of blood pressure at night in comparison of day on mean arterial blood pressure): On Ambulatory blood pressure monitoring.
Patients with accelerated hypertension (Stage III).
Patients with secondary hypertension: Renal disease, Endocrinopathies.
Patients with history of target organ damage (Nephropathy, Retinopathy).
Patients with other cardiac disorders Example: Heart failure (EF <50%), congenital cardiac heart disease, atrial fibrillation infection.
Major Stroke or recent stroke.
Patients on the drug interacting with Melatonin.
Circadian rhythm sleep wake disorders (DSPS, ASPS, Shift workers)
No acute coronary syndrome (PCI and CABg) with in 3 Month.
Major depressive disorder on medication.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Establishment of dipping pattern (10% reduction in nocturnal blood pressure from than daytime) of blood pressure on ambulatory blood pressure monitoring.Timepoint: At 3 Months and 6 Months
- Secondary Outcome Measures
Name Time Method To compare re-establishment of dipping between melatonin and placebo according to prakriti type. <br/ ><br>Improvement in sleep qualityTimepoint: 6 months