The study of the effects of melatonin on nocturnal blood pressure fluctuation in patients with obstructive sleep apnea
Phase 1
Recruiting
- Conditions
- Obstructive sleep apnea.Obstructive sleep apnea (adult) (pediatric)G47.33
- Registration Number
- IRCT20221023056278N1
- Lead Sponsor
- IMAD
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age between 18 and 75 years
Diagnosis of OSA [apnea-hypopnea index (AHI) =?15]
BP =?180/110 mmHg
Exclusion Criteria
Patients who have been hospitalized for cardiac or respiratory exacerbations less than 6 weeks prior to recruiting
Those with autonomic nervous system diseases or endocrine disorders which might influence BP
BP =?180/110 mmHg
Those unwilling to participate in the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic and diastolic BP, serum ACE level and cortisol. Timepoint: Before and one month after the intervention. Method of measurement: Using polysomnography and laboratory evaluation.
- Secondary Outcome Measures
Name Time Method