A comparison of azithromycin and ofloxacin in the treatment of typhoid in adult patients in Laos
Completed
- Conditions
- Typhoid feverInfections and Infestations
- Registration Number
- ISRCTN66534807
- Lead Sponsor
- niversity of Oxford (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 88
Inclusion Criteria
1. Adult (more than or equal to 15 years, either sex) non-pregnant patients with suspected or blood culture proven typhoid
2. Fever more than 37.5 °C
3. Informed written consent to the study
4. Able to stay in hospital for seven days
5. Able to take oral medication
6. Body weight more than 40 kg
7. Likely to be able to complete six months follow up
8. None of the exclusion criteria
Exclusion Criteria
1. Known hypersensitivity to ofloxacin or azithromycin
2. Administration of chloramphenicol, co-trimoxazole, ampicillin, azithromycin or a fluoroquinolone during the previous week
3. Pregnancy or breast feeding
4. Contraindications to ofloxacin or azithromycin
5. Evidence for severe typhoid
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome measures are fever clearance, cure rate, relapse rate and S. typhi stool carriage rate.
- Secondary Outcome Measures
Name Time Method o secondary outcome measures