PTSD in children: underlying mechanisms and treatment

Recruiting

• Conditions: Post-traumatic stress disorder; stress complaints; 10002861

• Registration Number: NL-OMON36199
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

Involvement in at least one traumatic event
Age 8 through 17 years

Exclusion Criteria

- Acute suicidal
- Mental disorders due to a general medical condition
- Meeting the criteria of one of the following DSM IV TR-diagnosis: psychotic disorder, substance use disorder, pervasive develop disorder (e.g. autism), mental retardation
- Known presence of a significant medical illness including cardiac arrhythmias and epilepsia
- Pregnancy
- Gross obesity (weight greater than 150% of ideal body weight) or growth failure (height under 3rd percentile)
- The use or presence of medication with central nervous system or HPA axis effects within the 2 weeks before measures
- Claustrophobia
- Presence of any metal or electrical conductive implants or foreign bodies

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Neuroimaging: (f)MRI, DTI,<br /><br>Physiological measures: Heartrate(variability), Skin conductance<br /><br>Endocrinological measures: Cortisolconcentration in saliva</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>CAPS-CA (interview to help diagnose PTSD)<br /><br>ADIS (interview to screen for anxiety disorders)<br /><br>cPTCI, RCADS, CRIES, SDQ, Kidscreen</p><br>