Establishment of national neuropathology infrastructure for brain autopsies in demetia

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 160

Inclusion Criteria

Inclusion criteria
1. A donor, deputy or bereaved family member is provided with sufficient explanation from a staff member of a Seoul National University Hospital or a brain bank staff member of a Seoul National University Hospital. It is possible to donate the brain if one write Application for registration of brain donors” in the case of pre-death informed consent, and "consent to autopsy" and "consent for brain research" in the case of after-death informed consent.

1-1. Clinical evaluation, neuropsychological test, brain imaging test, blood sampling, and basic blood test are performed only for those who are 18 years of age or older.

2. To the extent permitted by law, body resources from medical institutions other than Seoul National University Hospital or brain banks other than the brain bank of Seoul National University Hospital can be submitted.

In case of 1 and 2, the specimen such as brain tissue, blood, and body fluids obtained from the corpse or deposited body material is stored in the brain bank of Seoul National University Hospital.

Exclusion Criteria

Exclusion criteria
1. If the quality of the resource is bad enough that it is not worth keeping it
2. If the problem of the corpse (brain) acquisition procedure is confirmed late
3. Any other reason for cancellation of the brain donation
In case of 1, 2, and 3, they are excluded based on the decision of the Steering Committee of Seoul National University Hospital Brain Bank.
4. Neuropsychological tests are not carried out in case of severe visual loss or deterioration of auditory ability that interferes with the performance of neuropsychological tests.

Study & Design

Study Type: Observational Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
europathologic diagnosis;Final clinical diagnosis on cognitive dysfunction

Secondary Outcome Measures

Name	Time	Method
Biological resources (brain tissue and cerebrospinal fluid);Biological resources (serum, plasma, DNA);Image resources (MRI, amyloid PET);Clinical evaluation: demographic information, overall clinical assessment (including family history, aggravation of illness, medication, physical measurements, NPI, UPDRS, etc.);Neuropsychological tests, CERAD-K Neuropsychological tests